TITLE : Inhibitors for Androgen Receptor Activation Surfaces
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منابع مشابه
P-91: Androgen Associated Gene Polymorphism(s) in Women with Polycystic Ovary Syndrome from South Indian Population
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting 4-12% of reproductive women worldwide; characterized by chronic anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovaries on ultrasound scan. Ovarian androgen overproduction is the key pathophysiologic feature of PCOS. A number of genes encoding major enzymes of the androgen meta...
متن کاملA yeast screen system for aromatase inhibitors and ligands for androgen receptor: yeast cells transformed with aromatase and androgen receptor.
Endocrine disruptors are hormone mimics that modify hormonal action in humans and animals. It is thought that some endocrine disruptors modify estrogen and androgen action in humans and animals by suppressing aromatase activity. Aromatase cytochrome P450 is the key enzyme that converts C19 androgens to aromatic C18 estrogenic steroids. We have developed a novel aromatase inhibitor screening met...
متن کاملP-202: StuI Polymorphism on the Androgen Receptor Gene in Women with Endometriosis
Background: Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and a...
متن کاملHistone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer.
Transcriptional activity of the androgen receptor (AR) is crucial for growth and survival of prostate cancer even upon development of resistance to androgen ablation and antiandrogen therapies. Therefore, novel therapies that can suppress AR transcriptional activity when conventional hormone therapies fail are needed. Here, we show that histone deacetylase (HDAC) inhibitors, including SAHA (vor...
متن کاملWNT SIGNALLING REGULATES SELF-RENEWAL AND DIFFERENTIATION OF PROSTATE CANCER CELLS WITH STEM CELL CHARACTERISTICS Running Title WNT regulates prostate cancer stem cell attributes Key words prostate cancer, stem cell, WNT, androgen receptor, LNCaP, prostasphere Authors
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in nonadherent cultures. Prostaspheres exhibited heterogeneous expression of proliferation, differentiation and stem cell associated makers CD44, ABCG2 and CD133. Treatment with WNT inhibitors reduced both prostasphere si...
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